Road user charging: a policy whose time has finally arrived

Modeling and Simulation in Mining - Its Time Has Finally Arrived

Functional coronary revascularization: an idea whose time has arrived.

The decision to perform coronary revascularization is correctly based on a combination of factors, including the presence and severity of symptoms, objective evidence of ischemia, the volume of myocardium at jeopardy, the presence of viable myocardium with the potential for reversible dysfunction, and demonstration of significant coronary stenoses that are treatable with current techniques. Add...

XML Databases: An Idea Whose Time has Finally Come

The demand for an efficient means to manage XML content is increasing proportionately with our increased dependence on XML-based applications, messaging and distributed computing. This white paper examines current market forces, available technology and the emerging XML landscape to gauge the value and, by extension, the demand for an XML-centric database that can sit alongside the many flavors...

Immunotherapy for Lung Cancer: Has it Finally Arrived?

The possible link between infection/inflammation/immune activation and a cancer patient's outcome from both a causative and outcome point of view has long been postulated. Substantial progress in the understanding of tumor-associated antigens/epitopes, immune cellular subpopulations, cytokine pathways/expression, the tumor microenvironment, and the balance between tumor-immune suppression and s...

Management decisions in aortic regurgitation: has the time for exercise assessment finally arrived?

Aortic regurgitation (AR) is a problem of moderate but increasing frequency. Current data suggest that AR of some degree affects approximately 5% to 10% of the population and increases in frequency and severity with age (1). When severe, AR gradually leads to irreversible left ventricular (LV) dysfunction, heart failure, and death; indeed, sudden death occurs in asymptomatic patients when intri...